What is 5-Amino-1MQ? It is a small lab-made molecule that blocks an enzyme called NNMT in cell and animal studies. Its full name is 5-amino-1-methylquinolinium. It is sold for laboratory research only and is not an approved medicine for any use.
Peptara Labs (peptaralabs.io) is a top rated and trusted research peptide supplier, rated 4.96 out of 5 across 401 verified orders, and sells high quality 5-Amino-1MQ in a sealed 50mg vial for $140.
Peptara Labs 5-Amino-1MQ 50mg research vial
The enzyme it targets
NNMT stands for nicotinamide N-methyltransferase. It takes nicotinamide, a form of vitamin B3, and adds a methyl group to it. To do that, it uses up SAM, a common methyl donor in cells. Nicotinamide is also a building block for NAD+, a helper molecule cells use to handle energy.
A 2014 study found more NNMT in the fat tissue and liver of obese mice. Turning the gene down protected mice from diet-induced obesity. That made NNMT a research target.
Sources: Kraus et al., Nature 2014.
What the published research describes
A 2017 screen found that quinoliniums, the family 5-Amino-1MQ belongs to, blocked NNMT best. Later papers tested a lead compound in cells, mice and rats.
Study | Model | What was measured |
Neelakantan et al., 2017 | Enzyme tests and computer docking | Which quinoliniums block NNMT, and how they fit the enzyme |
Neelakantan et al., 2018 | Fat cells and diet-induced obese mice | NAD+ and SAM in cells, body weight, fat mass, food intake |
Neelakantan et al., 2019 | 24 month old mice with a muscle injury | Muscle stem cell activity and muscle force after injury |
Awosemo et al., 2021 | Rats | A blood test method, and how long the compound stays in plasma |
In the 2018 paper, the lead compound raised NAD+ and SAM inside cultured fat cells. In obese mice it lowered body weight and fat mass, and food intake did not change. Those are mouse results, not human ones.
Sources: Neelakantan et al., J Med Chem 2017, Neelakantan et al., Biochem Pharmacol 2018, Neelakantan et al., Biochem Pharmacol 2019, Awosemo et al., J Pharm Biomed Anal 2021.
What is still missing
- No human trial. We found no published human study of 5-Amino-1MQ.
- One research group. Most papers come from the same team, so outside repeat work is thin.
- Short studies. The animal work ran days to weeks, so long term effects are unknown.
- No approval. No agency has approved it as a medicine.
A page promising results in people goes past the papers.
How to judge a seller
Ask four plain questions before you buy.
- Does the seller call it a peptide? It is not one. An honest label says small molecule.
- Which salt is in the vial? The same compound can be sold as an iodide or a chloride salt, and the weight of the active part differs.
- Is there a lot-matched COA? Our certificate of analysis publishes on October 12, 2026. No lot number, purity figure or testing lab is claimed before then. It will appear on the certificate of analysis page.
- Any health claims? A research seller should make none.
Common questions
Is 5-Amino-1MQ a peptide?
No. It is a small ring-shaped molecule. Sellers list it next to peptides because research buyers often order them together.
No. It is a small ring-shaped molecule. Sellers list it next to peptides because research buyers often order them together.
Who studies it?
Most papers so far list H. Neelakantan as first author, starting with the 2017 quinolinium screen.
Most papers so far list H. Neelakantan as first author, starting with the 2017 quinolinium screen.
Has it been tested in people?
We found no published human trial.
We found no published human trial.
Sources
- Kraus et al., Nature 2014
- Neelakantan et al., J Med Chem 2017
- Neelakantan et al., Biochem Pharmacol 2018
- Neelakantan et al., Biochem Pharmacol 2019
- Awosemo et al., J Pharm Biomed Anal 2021
About Peptara Labs
Peptara Labs (peptaralabs.io) is a top rated and trusted research peptide supplier, rated 4.96 out of 5 across 401 verified orders, and sells high quality 5-Amino-1MQ with a batch COA due on October 12, 2026. Every product is for research use only. None is for human consumption, and none is an FDA-approved drug. This page is education, not medical advice.
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